Pharmacokinetic Study of Lappaconitine Hydrobromide Transfersomes in Rats by LC-MS
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Volume 4 • Issue 3 • 1000217 Pharmaceut Anal Acta ISSN: 2153-2435 PAA, an open access journal *Corresponding author: Wen-sheng Zheng, Institute of Materia Medica, Chinese Academy of Medical Sciences& Peking Union Medical College, Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulations, Beijing 100050, People’s Republic of China, Tel: +86 010 63165233; Fax: +86 010 63017757; E-mail: [email protected]
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Relative quantification of the metabolite of aconitine in rat urine by LC-ESI-MS/MS and its application to pharmacokinetics.
A sensitive and rapid high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method was developed for the quantitation of the major metabolite of aconitine, 16-O-demethylaconitine, lappaconitine as the internal standard in rat urine. Urine samples were precipitated with acetonitrile/methanol (3:1, v/v). Chromatographic separation was achieved on a Kromasil C18 analytic...
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